7/27—SARS-CoV-2 genomic variations associated with mortality rate of COVID-19
We classified 28 countries into three clusters showing different fatality rates of COVID-19. In correlation analyses, we identified that ORF1ab 4715L and S protein 614G variants […] showed significant positive correlations with fatality rates (r = 0.41, P = 0.029 and r = 0.43, P = 0.022, respectively). Our findings suggest that SARS-CoV-2 mutations […] might affect the susceptibility to SARS-CoV-2 infection or severity of COVID-19 (Toyoshima et al. 2020).
Association of Social Distancing, Population Density, and Temperature With the Instantaneous Reproduction Number of SARS-CoV-2 in Counties Across the United States
In this cohort study of 211 counties in 46 states, social distancing, temperate weather, and lower population density were associated with a decrease in the instantaneous reproduction number of SARS-CoV-2. Of these county-specific factors, social distancing appeared to have the most substantial association with a reduction in SARS-CoV-2 transmission.
For-profit long-term care homes and the risk of COVID-19 outbreaks and resident deaths
For-profit status is associated with the extent of an outbreak of COVID-19 in long-term care homes and the number of resident deaths, but not the likelihood of outbreaks.
Estimation of Viral Aerosol Emissions From Simulated Individuals With Asymptomatic to Moderate Coronavirus Disease 2019
The results suggest that only few people with very high viral load pose an infection risk in poorly ventilated closed environments […]. Strict respiratory protection may be needed when there is a chance to be in the same small room with an individual, whether symptomatic or not, especially for a prolonged period.
Seroprevalence of Antibodies to SARS-CoV-2 in 10 Sites in the United States, March 23-May 12, 2020
Adjusted estimates of the proportion of persons seroreactive to the SARS-CoV-2 spike protein antibodies ranged from 1.0% in the San Francisco Bay area to 6.9% of persons in New York City. The estimated number of infections ranged from 6 to 24 times the number of reported cases. The findings may reflect the number of persons who had mild or no illness or who did not seek medical care or undergo testing but who still may have contributed to ongoing virus transmission in the population.
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